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Trends Biochem Sci. 2001 Feb;26(2):83-5.

The DAPIN family: a novel domain links apoptotic and interferon response proteins.

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  • 1metaGen Gesellschaft für Genomforschung mbH, 14195, Berlin, Germany.


We report the discovery of a protein domain, hereafter referred to as DAPIN, in diverse vertebrate and viral proteins that is associated with tumor biology, apoptosis and inflammation. Based on a secondary structure prediction, we suggest an all-alpha fold for DAPIN, which is also adopted by apoptotic protein domains of the CARD, death domain and death effector domain type.

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