Format

Send to

Choose Destination
See comment in PubMed Commons below
Pharmacol Biochem Behav. 2000 Dec;67(4):801-8.

Genetic, sex, and early environmental effects on the voluntary alcohol intake in Wistar rats.

Author information

  • 1Department of Biological Psychology, Vrije Universiteit, Vander Boechorststraa 1, 1081 BT Amsterdam, Netherlands. f.sluyter@psy.vu.nl

Abstract

The aim of this study was to investigate the effects of genetic, sex, and early environmental factors on the voluntary alcohol intake in Wistar rats. Genetic correlates were examined by comparing animals pharmacogenetically selected for high susceptibility to apomorphine (APO-SUS) with animals selected for low susceptibility (APO-UNSUS). Early environmental factors were investigated through postnatal manipulations (cross-fostering in APO-SUS and maternal deprivation in APO-UNSUS). Voluntary alcohol intake was measured using a two-bottle, free-choice protocol, in which animals could choose either water or an ascending series of alcohol concentrations every second day. Genetic correlates were only observed in male rats, with APO-UNSUS animals consuming more alcohol than APO-SUS animals. No effect of the early postnatal manipulations was detected: neither cross-fostering nor maternal deprivation influenced the voluntary alcohol intake. As for the influence of gender on ethanol self-administration, APO-SUS females consume more alcohol than APO-SUS males, while no sex differences were observed in APO-UNSUS animals.

PMID:
11166071
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk