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Immunity. 2000 Dec;13(6):841-51.

Selective export of MHC class I molecules from the ER after their dissociation from TAP.

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  • 1Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA.

Erratum in

  • Immunity 2001 Feb;14(2):following 204.


It has been assumed that upon dissociation from TAP, MHC class I molecules exit the ER by nonselective bulk flow. We now show that exit must occur by association with cargo receptors. Inconsistent with exit by bulk flow, loading of MHC class I molecules with high-affinity peptides triggers dissociation from TAP but has no effect on rates of ER-to-Golgi transport. Moreover, peptide-loaded MHC class I molecules accumulate at ER exit sites from which TAP molecules are excluded. Consistent with receptor-mediated exit, ER-to-Golgi transport of MHC class I molecules is independent of their cytoplasmic tails, which themselves lack ER export motifs. In addition, we show that MHC class I molecules associate with the putative cargo receptor BAP31.

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