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Cell. 2000 Dec 22;103(7):1009-17.

Mop3 is an essential component of the master circadian pacemaker in mammals.

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  • 1The McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison, WI 53706, USA.

Abstract

Circadian oscillations in mammalian physiology and behavior are regulated by an endogenous biological clock. Here we show that loss of the PAS protein MOP3 (also known as BMAL1) in mice results in immediate and complete loss of circadian rhythmicity in constant darkness. Additionally, locomotor activity in light-dark (LD) cycles is impaired and activity levels are reduced in Mop3-/- mice. Analysis of Period gene expression in the suprachiasmatic nucleus (SCN) indicates that these behavioral phenotypes arise from loss of circadian function at the molecular level. These results provide genetic evidence that MOP3 is the bona fide heterodimeric partner of mCLOCK. Furthermore, these data demonstrate that MOP3 is a nonredundant and essential component of the circadian pacemaker in mammals.

PMID:
11163178
[PubMed - indexed for MEDLINE]
PMCID:
PMC3779439
Free PMC Article
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