Curr Opin Genet Dev. 2001 Feb;11(1):83-90.

Mitotic checkpoints: from yeast to cancer.

Source

Cell Biology Program, Memorial Sloan-Kettering Cancer Center and the Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, Box 241, 1275 York Avenue, New York, New York 10021, USA.

Abstract

Separation of chromosomes during mitosis is monitored by a checkpoint that leads to cell-cycle arrest if the chromosomes are not properly attached to the mitotic spindle. Molecular mechanisms controlling this checkpoint have been identified. In addition, loss of this checkpoint has been shown to result in chromosome missegregation in higher eukaryotes and may contribute to the genomic instability observed in human cancers.

PMID:: 11163156; [PubMed - indexed for MEDLINE]

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GM 54601/GM/NIGMS NIH HHS/United States

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Cancer - MedlinePlus Health Information

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Saccharomyces Genome Database

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