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Curr Opin Genet Dev. 2001 Feb;11(1):64-70.

Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?

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  • 1Chromosome Replication Laboratory, ICRF Clare Hall Laboratories, Blanche Lane, South Mimms, EN6 3LD, Hertfordshire,


The MCM2-7 complex is essential for both the initiation and elongation phases of eukaryotic chromosome replication. There is some evidence that MCM2-7 proteins may act as a DNA helicase; at the same time, a variety of other DNA helicases have also been implicated in the replication of eukaryotic chromosomes.

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