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Curr Opin Genet Dev. 2001 Feb;11(1):41-7.

Cytoskeletal changes in cell transformation and tumorigenesis.

Author information

  • 1Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, New York 11724, USA. pawlak@cshl.org

Abstract

Research during the past couple of years has provided important new information as to how the actin cytoskeleton contributes to growth control in both normal and transformed cells. The cytoskeleton can no longer be viewed as simply a structural framework playing a role in cell shape and motile events such as cell movement, intracellular transport, contractile-ring formation and chromosome movement. More recent experiments show that the cytoskeleton plays a critical role in the regulation of various cellular processes linked to transformation including proliferation, contact inhibition, anchorage-independent cell growth, and apoptosis.

PMID:
11163149
[PubMed - indexed for MEDLINE]
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