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1: Biochem Biophys Res Commun. 2001 Jan 19;280(2):558-60.Click here to read Links

Inflammatory activation of prostaglandin production by microglial cells antagonized by amyloid peptide.

Balboa MA, Balsinde J, Dennis EA.

Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California, 92093-0601, USA.

The murine cell line MMGT-16 is of microglial origin and capable of releasing immunoinflammatory cytokines. When stimulated by the proinflammatory stimulus lipopolysaccharide (LPS), MMGT-16 cells secrete large amounts of prostaglandin E(2) (PGE(2)). This PGE(2) production is nearly abolished if amyloid beta-peptide (Abeta (1-40)) is present in the incubation medium. In addition, Abeta (1-40) inhibits cyclooxygenase-2 (COX-2) induction by LPS. Since these effects are not reproduced by the reverse control Abeta (40-1), these results suggest a novel, intriguing modulatory role for amyloid beta peptide in the inflammatory response of microglial cells. Copyright 2001 Academic Press.

PMID: 11162555 [PubMed - indexed for MEDLINE]

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