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Biochem Biophys Res Commun. 2001 Jan 19;280(2):522-5.

Inhibition of hBD-3, but not hBD-1 and hBD-2, mRNA expression by corticosteroids.

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  • 1Department of Infectious Diseases, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.


Intensive use of corticosteroids may be accompanied by increased susceptibility to infections; hence, we investigated the effects of dexamethasone on the expression of antimicrobial peptides, termed human beta-defensins (hBD), by cultured bronchial epithelial cells and mononuclear phagocytes. The results revealed that dexamethasone inhibited the (stimulated) expression of mRNA for hBD-3, but not hBD-1 and hBD-2 by these epithelial cells. Dexamethasone did not affect the (stimulated) mRNA expression of hBD-1 and hBD-2 by mononuclear phagocytes, whereas these cells did not express hBD-3 mRNA.

Copyright 2001 Academic Press.

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