Antimicrob Agents Chemother. 2001 Feb;45(2):428-32.

Cross-resistance between triclosan and antibiotics in Pseudomonas aeruginosa is mediated by multidrug efflux pumps: exposure of a susceptible mutant strain to triclosan selects nfxB mutants overexpressing MexCD-OprJ.

Chuanchuen R, Beinlich K, Hoang TT, Becher A, Karkhoff-Schweizer RR, Schweizer HP.

Source

Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523-1677, USA.

Abstract

Triclosan is an antiseptic frequently added to items as diverse as soaps, lotions, toothpaste, and many commonly used household fabrics and plastics. Although wild-type Pseudomonas aeruginosa expresses the triclosan target enoyl-acyl carrier protein reductase, it is triclosan resistant due to expression of the MexAB-OprM efflux system. Exposure of a susceptible Delta(mexAB-oprM) strain to triclosan selected multidrug-resistant bacteria at high frequencies. These bacteria hyperexpressed the MexCD-OprJ efflux system due to mutations in its regulatory gene, nfxB. The MICs of several drugs for these mutants were increased up to 500-fold, including the MIC of ciprofloxacin, which was increased 94-fold. Whereas the MexEF-OprN efflux system also participated in triclosan efflux, this antimicrobial was not a substrate for MexXY-OprM.

PMID:: 11158736; [PubMed - indexed for MEDLINE]
PMCID: PMC90308

Free PMC Article

Images from this publication.See all images (1) Free text

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

The MexJK efflux pump of Pseudomonas aeruginosa requires OprM for antibiotic efflux but not for efflux of triclosan. [J Bacteriol. 2002]
The MexJK efflux pump of Pseudomonas aeruginosa requires OprM for antibiotic efflux but not for efflux of triclosan.
Chuanchuen R, Narasaki CT, Schweizer HP. J Bacteriol. 2002 Sep; 184(18):5036-44.
Efflux-mediated resistance to tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1. [Antimicrob Agents Chemother. 2003]
Efflux-mediated resistance to tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1.
Dean CR, Visalli MA, Projan SJ, Sum PE, Bradford PA. Antimicrob Agents Chemother. 2003 Mar; 47(3):972-8.
Overexpression of the mexC-mexD-oprJ efflux operon in nfxB-type multidrug-resistant strains of Pseudomonas aeruginosa. [Mol Microbiol. 1996]
Overexpression of the mexC-mexD-oprJ efflux operon in nfxB-type multidrug-resistant strains of Pseudomonas aeruginosa.
Poole K, Gotoh N, Tsujimoto H, Zhao Q, Wada A, Yamasaki T, Neshat S, Yamagishi J, Li XZ, Nishino T. Mol Microbiol. 1996 Aug; 21(4):713-24.
Review Efflux as a mechanism of resistance to antimicrobials in Pseudomonas aeruginosa and related bacteria: unanswered questions. [Genet Mol Res. 2003]
Review Efflux as a mechanism of resistance to antimicrobials in Pseudomonas aeruginosa and related bacteria: unanswered questions.
Schweizer HP. Genet Mol Res. 2003 Mar 31; 2(1):48-62. Epub 2003 Mar 31.
Review [Antibiotic efflux, a mechanism of multiple resistance in Pseudomonas aeruginosa]. [Bull Acad Natl Med. 1998]
Review [Antibiotic efflux, a mechanism of multiple resistance in Pseudomonas aeruginosa].
Pechère JC, Michéa-Hamzhepour M, Köhler T. Bull Acad Natl Med. 1998; 182(3):599-612; discussion 613-5.

See reviews... See all...

Cited by 30 PubMed Central articles

Antimicrobial Activity of Medicated Soaps Commonly Used By Dar es Salaam Residents in Tanzania. [Indian J Pharm Sci. 2011]
Antimicrobial Activity of Medicated Soaps Commonly Used By Dar es Salaam Residents in Tanzania.
Mwambete KD, Lyombe F. Indian J Pharm Sci. 2011 Jan; 73(1):92-8.
The binding of triclosan to SmeT, the repressor of the multidrug efflux pump SmeDEF, induces antibiotic resistance in Stenotrophomonas maltophilia. [PLoS Pathog. 2011]
The binding of triclosan to SmeT, the repressor of the multidrug efflux pump SmeDEF, induces antibiotic resistance in Stenotrophomonas maltophilia.
Hernández A, Ruiz FM, Romero A, Martínez JL. PLoS Pathog. 2011 Jun; 7(6):e1002103. Epub 2011 Jun 30.
Inhibitory effect of biocides on the viable masses and matrices of Staphylococcus aureus and Pseudomonas aeruginosa biofilms. [Appl Environ Microbiol. 2010]
Inhibitory effect of biocides on the viable masses and matrices of Staphylococcus aureus and Pseudomonas aeruginosa biofilms.
Toté K, Horemans T, Vanden Berghe D, Maes L, Cos P. Appl Environ Microbiol. 2010 May; 76(10):3135-42. Epub 2010 Apr 2.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Cross-resistance between triclosan and antibiotics in Pseudomonas aeruginosa is ...
Cross-resistance between triclosan and antibiotics in Pseudomonas aeruginosa is mediated by multidrug efflux pumps: exposure of a susceptible mutant strain to triclosan selects nfxB mutants overexpressing MexCD-OprJ.
Antimicrob Agents Chemother. 2001 Feb ;45(2):428-32.

PubMed
Idiopathic infantile arterial calcification: imaging evaluation and the usefulne...
Idiopathic infantile arterial calcification: imaging evaluation and the usefulness of MR angiography.
Pediatr Radiol. 2006 Mar ;36(3):247-53. Epub 2006 Jan 21 .

PubMed
A rare case of mucoepidermoid carcinoma of the nasal cavity.
A rare case of mucoepidermoid carcinoma of the nasal cavity.
Ear Nose Throat J. 2002 Aug ;81(8):519-22.

PubMed
Thyroid dysfunction: reproduction and postpartum thyroiditis.
Thyroid dysfunction: reproduction and postpartum thyroiditis.
Semin Reprod Med. 2002 Nov ;20(4):381-8.

PubMed
Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylatio...
Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1.
J Biol Chem. 2002 Dec 6 ;277(49):47878-84. Epub 2002 Oct 7 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Cross-resistance between triclosan and antibiotics in Pseudomonas aeruginosa is mediated by multidrug efflux pumps: exposure of a susceptible mutant strain to triclosan selects nfxB mutants overexpressing MexCD-OprJ.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Related citations

Cited by 30 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information