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J Clin Microbiol. 2001 Feb;39(2):691-5.

Rapid detection of mutations in the 23S rRNA gene of Helicobacter pylori that confers resistance to clarithromycin treatment to the bacterium.

Author information

  • 1The Institute for Adult Diseases, Asahi Life Foundation, 1-9-14 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. m-matsumura@asahi-life.or.jp

Abstract

We developed a new method capable of detecting point mutations in the 23S rRNA gene of Helicobacter pylori using a LightCycler. Our method can detect a mutation in this gene in less than 1 h and can process many samples at once, thereby contributing to the selection of patients suitable for clarithromycin-based therapy.

PMID:
11158129
[PubMed - indexed for MEDLINE]
PMCID:
PMC87798
Free PMC Article
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