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Vitam Horm. 2001;61:267-97.

Multiple biosynthetic pathways for vitamin B12: variations on a central theme.

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  • 1Center for Biological NMR, Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA.


The manner in which vitamin B12 is synthesized is detailed with emphasis on the different mechanisms for ring contraction encountered in aerobic and anaerobic organisms. The aerobic process utilizes two enzymes and is dependent on molecular oxygen, in stark contrast to the anaerobic mechanism which is controlled by cobalt and requires only one enzyme.

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