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J Womens Health Gend Based Med. 2000 Dec;9(10):1061-70.

Involving minority and underrepresented women in clinical trials: the National Centers of Excellence in Women's Health.

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  • 1Department of Family and Child Nursing, School of Nursing, University of Washington, Seattle, Washington, USA.


Recent attention to reducing health disparities among population groups has focused on the need to include in clinical studies, especially clinical trials, participants who represent the diversity of the populations to which study results will be applied. While scientists generally applaud the goal of broadening the characteristics of participants in clinical trials, they are faced with multiple challenges as they seek to include historically underrepresented populations in their research. This article examines the historical and sociocultural context of participation by underrepresented groups, especially women and minorities, in clinical trials, identifies major barriers and challenges facing researchers, and suggests strategies for meeting these challenges. The article draws upon the experiences of the investigators affiliated with the National Centers of Excellence of Women's Health (CoEs).

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