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Nat Cell Biol. 2001 Jan;3(1):E12-4.

Together until separin do us part.

Author information

  • Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. angelika@mit.edu

Abstract

Loss of sister-chromatid cohesion triggers chromosome segregation. Several recent reports show that the protease Esp1 cleaves the cohesin subunit Scc1/Mcd1 to induce sister-chromatid segregation in yeast and vertebrates. This finding indicates that cohesin cleavage may control sister-chromatid separation in all vertebrates.

PMID:
11146641
[PubMed - indexed for MEDLINE]
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