Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Control Clin Trials. 2000 Dec;21(6):527-39.

Practical guidelines for multiplicity adjustment in clinical trials.

Author information

  • 1Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD 20892-7938, USA. ProschaM@nih.gov

Abstract

Multiplicity in clinical trials may appear under several different guises: multiple endpoints, multiple treatment arm comparisons, and multiple looks at the data during interim monitoring, to name a few. It is well recognized by statisticians and nonstatisticians alike that multiplicity inflates the type I error rate of the experiment, and this has prompted the development of many multiple comparison adjustment procedures. What has remained one of the thornier and more controversial points of contention among trialists today is the philosophy surrounding the need for multiplicity adjustment in clinical trials. This paper provides guidelines on how to deal with this complex issue in a practical manner. Through a series of scenarios and examples, we illustrate the fundamental issues surrounding the concept of multiplicity and point to some key questions one should ask when deliberating on the necessity and extent of adjustment for multiple comparisons. Control Clin Trials 2000;21:527-539

Comment in

  • Coping with multiple testing. [Control Clin Trials. 2001]
PMID:
11146147
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk