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Curr Biol. 2000 Dec 14-28;10(24):R899-903.

X inactivation: Tsix and Xist as yin and yang.

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  • 1University of California San Francisco, Department of Biochemistry and Biophysics, 513 Parnassus Avenue, Box 0448, San Francisco, California 94143, USA.


A new study shows that expression of Tsix, an antisense Xist gene, can be controlled by imprinting, and that high Tsix activity during X inactivation can protect the future active X chromosome from silencing by Xist. Tsix and Xist seem to have a yin and yang relationship, with opposite effects on X inactivation.

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