Phys Rev Lett. 2000 Dec 25;85(26 Pt 1):5655-8.

Enhanced diffusion in active intracellular transport.

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Department of Materials and Interfaces, Weizmann Institute of Science, Rehovot 76100, Israel.

Abstract

We show that within a living eukaryotic cell, mean square displacement of an engulfed microsphere shows enhanced diffusion scaling as t(3/2) at short times, with a clear crossover to subdiffusive or ordinary diffusion scaling at longer times. The motion, observed nearby the nucleus, is due to interactions with microtubule-associated motor proteins rather than thermal Brownian motion. We propose that time-dependent friction introduced by the intracellular polymer networks leads to sub-ballistic motion, analogous to subdiffusion observed in passive networks of semiflexible biopolymers.

PMID:: 11136070; [PubMed - indexed for MEDLINE]

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