Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Nat Neurosci. 2001 Jan;4(1):72-7.

Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch.

Author information

  • 1Atkinson Pain Research Laboratory, Division of Neurosurgery, Barrow Neurological Institute, 350 W. Thomas Road, Phoenix, Arizona 85013, USA. dandrew@chw.edu

Abstract

We found a class of lamina I spinothalamic tract (STT) neurons selectively excited by iontophoretic histamine. The responses of this class of neurons parallel the pure itching sensation this stimulus elicits in humans, and match the responses of peripheral C-fibers that have similar selectivity. These neurons have distinct central conduction velocities and thalamic projections, indicating that they constitute a unique subset of STT neurons. These findings can explain why a lesion of the lateral STT disrupts itch along with pain and temperature sensations. Our findings provide strong evidence that itch is subserved by specific neural elements both peripherally and centrally.

Comment in

PMID:
11135647
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk