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Bioessays. 2001 Jan;23(1):54-61.

Patterning the pharyngeal arches.

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  • 1Molecular Neurobiology Group, MRC Centre for Developmental Neurobiology, Kings College, London, UK. anthony.graham@kcl.ac.uk

Abstract

The presence of a muscularised pharynx with skeletal support is a fundamental vertebrate characteristic. Developmentally, the pharynx arises from the pharyngeal arches on either side of the head of vertebrate embryos. The development of the pharyngeal arches is complex involving a number of disparate embryonic populations, ectoderm, endoderm, neural crest and mesoderm, which must be co-ordinated to generate the components and overall identity of each of the arches. Previous studies suggested that it is the neural crest that plays a pivotal role in patterning the pharyngeal arches. It is now also becoming clear, however, that there are crest-independent patterning mechanisms. Therefore, pharyngeal arch patterning is more complex than was previously believed and there must be an integration of crest-dependent and -independent patterning mechanisms. BioEssays 23:54-61, 2001.

Copyright 2001 John Wiley & Sons, Inc.

PMID:
11135309
[PubMed - indexed for MEDLINE]
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