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    Cell Mol Life Sci. 2000 Nov;57(12):1682-94.

    Hedgehog signaling in vertebrate and invertebrate limb patterning.

    Capdevila J, Johnson RL.

    Source

    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla California 92037-1099, USA. jcapdevila@ems.salk.edu

    Abstract

    Invertebrate and vertebrate limbs have very different anatomies and modes of development. Despite these differences, recent studies demonstrate that a significant overlap exists in the signals used to pattern invertebrate and vertebrate limbs. One of these signaling molecules is Hedgehog, a secreted protein that functions to coordinate growth and proliferation along the anterior-posterior axis of developing limbs. Recent studies indicate that the mechanism of action, regulation and function of Hedgehog signaling in Drosophila and vertebrate limb development are often quite similar, yet at other times are distinct. Here we highlight the similarities and differences between the use of Hedgehog signaling in these two systems.

    PMID:
    11130175
    [PubMed - indexed for MEDLINE]

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