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Aromatic compound-dependent Brucella suis is attenuated in both cultured cells and mouse models.
INSERM U431, Faculté de Médecine, 30900 Nîmes, France.
The aroC gene of the facultative intracellular pathogen Brucella suis was cloned and sequenced. The cloned aroC gene complements Escherichia coli and Salmonella enterica serovar Typhimurium aroC mutants. A B. suis aroC mutant was found to be unable to grow in a defined medium without aromatic compounds. The mutant was highly attenuated in tissue culture (THP1 macrophages and HeLa cells) and murine virulence models.
PMID: 11119550 [PubMed - indexed for MEDLINE]
PMCID: PMC97916
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Cited by 8 PubMed Central articles
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Targeting of the Brucella suis virulence factor histidinol dehydrogenase by histidinol analogues results in inhibition of intramacrophagic multiplication of the pathogen.
Joseph P, Abdo MR, Boigegrain RA, Montero JL, Winum JY, Köhler S.
Antimicrob Agents Chemother. 2007 Oct; 51(10):3752-5. Epub 2007 Aug 13.
[Antimicrob Agents Chemother. 2007]
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Deletion of znuA virulence factor attenuates Brucella abortus and confers protection against wild-type challenge.
Yang X, Becker T, Walters N, Pascual DW.
Infect Immun. 2006 Jul; 74(7):3874-9.
[Infect Immun. 2006]
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Health considerations regarding horizontal transfer of microbial transgenes present in genetically modified crops.
Kleter GA, Peijnenburg AA, Aarts HJ.
J Biomed Biotechnol. 2005; 2005(4):326-52.
[J Biomed Biotechnol. 2005]
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