Lancet. 2000 Nov 25;356(9244):1820-1.

Hereditary catalase deficiencies and increased risk of diabetes.

Abstract

Partial or near-total lack of erythrocyte catalase activity is a rare condition, generally thought to be benign. However, little is known of the frequency of common diseases of adult onset in human beings with catalase deficiency. We report that, in a series of Hungarian patients with catalase deficiency, there is a higher frequency of diabetes than in unaffected first-degree relatives and the general Hungarian population. We speculate that quantitative deficiency of catalase might predispose to cumulative oxidant damage of pancreatic beta-cells and diabetes.

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Lancet. 2001 Jan 27;357(9252):314.

PMID:: 11117918; [PubMed - indexed for MEDLINE]

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