Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor.

Dept. of Molecular and Cellular Biology, 7 Divinity Avenue, Cambridge, Harvard University, Massachusetts, MA 02138, USA. ggao@crystal.harvard.edu

In recent years, substantial progress has been made towards understanding the molecular basis for CD8 binding to class I MHC and the coreceptor's role in cytotoxic T-cell activation. Here, we review the structural, mechanistic and functional studies that point to a model of coordination of T-cell receptor and CD8 signaling that might provide the key to cytotoxic T-cell activation.

PMID: 11114424 [PubMed - indexed for MEDLINE]