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Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14388-93.

Gene expression profiles in normal and Otx2-/- early gastrulating mouse embryos.

Author information

  • 1Unité d'Embyologie Moléculaire, Unité de Recherche Associée 1947, Centre National de la Recherche Scientifique, and Laboratoire de Génomique des Microorganismes Pathogènes, Institut Pasteur, 25 Rue du Docteur Roux, 75724, Paris Cedex 15, France.

Abstract

The mouse Otx2 gene is a homeobox transcription factor required as early as gastrulation for the proper development of the head. We compared gene expression profiles in wild-type and Otx2(-/-) 6.5 days postcoitum embryos by using a serial analysis of gene expression assay adapted to microdissected structures. Among a broader list, the study of six genes found to be differentially expressed allows defining a role for Otx2 in the orchestration of cell movements leading to the adequate organization of the embryo before gastrulation.

PMID:
11114168
[PubMed - indexed for MEDLINE]
PMCID:
PMC18928
Free PMC Article

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