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Microbes Infect. 2000 Nov;2(13):1599-607.

Dental plaque formation.

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  • 1Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104, USA.


Dental plaque is a complex biofilm that accumulates on the hard tissues (teeth) in the oral cavity. Although over 500 bacterial species comprise plaque, colonization follows a regimented pattern with adhesion of initial colonizers to the enamel salivary pellicle followed by secondary colonization through interbacterial adhesion. A variety of adhesins and molecular interactions underlie these adhesive interactions and contribute to plaque development and ultimately to diseases such as caries and periodontal disease.

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