Acta Haematol. 2000;104(1):10-5.

Consequences of total and subtotal myeloperoxidase deficiency: risk or benefit ?

Kutter D, Devaquet P, Vanderstocken G, Paulus JM, Marchal V, Gothot A.

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Laboratoires réunis Kutter-Lieners-Hastert, Junglinster, Luxembourg.

Abstract

A group of 100 totally or subtotally myeloperoxidase (MPO)-deficient individuals was compared to a reference population of 118 probands selected at random. Data for a protective effect of the deficiency against cardiovascular damage are presented. On the other hand, a significantly higher occurrence of severe infections and chronic inflammatory processes was noted among the deficient patients. An increased incidence of cancer among the MPO-deficient individuals was not demonstrated.

PMID:: 11111115; [PubMed - indexed for MEDLINE]

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