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Biochim Biophys Acta. 2000 Dec 20;1498(2-3):153-61.

The ALG-2/AIP-complex, a modulator at the interface between cell proliferation and cell death? A hypothesis.

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  • 1Institute of Biochemistry, Swiss Federal Institute of Technology, Zurich, Switzerland. krebs@bc.biol.ethz.ch


During the development of an organism cell proliferation, differentiation and cell death are tightly balanced, and are controlled by a number of different regulators. Alterations in this balance are often observed in a variety of human diseases. The role of Ca(2+) as one of the key regulators of the cell is discussed with respect to two recently discovered proteins, ALG-2 and AIP, of which the former is a Ca(2+)-binding protein, and the latter is substrate to various kinases. The two proteins interact with each other in a Ca(2+)-dependent manner, and the role of the complex ALG-2/AIP as a possible modulator at the interface between cell proliferation and cell death is discussed.

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