Abstract
The immature brain is highly susceptible to seizures induced by a variety of insults, including hypoxia, fever, and trauma. Unlike early life epilepsy associated with congenital dysplasias or genetic abnormalities, insults induce a hyperexcitable state in a previously normal brain. Here we evaluate the epileptogenic effects of seizure-inducing stimuli on the developing brain, and the age and regional specificity of these effects.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Age Factors
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Brain / growth & development*
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Brain / pathology
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Brain / physiopathology
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Brain Injuries / complications*
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Brain Injuries / pathology
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Brain Injuries / physiopathology
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Causality
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Child
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Child, Preschool
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Disease Models, Animal
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Epilepsy / etiology*
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Epilepsy / pathology
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Epilepsy / physiopathology
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Epilepsy, Temporal Lobe / etiology
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Epilepsy, Temporal Lobe / pathology
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Epilepsy, Temporal Lobe / physiopathology
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Humans
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Hypoxia, Brain / complications
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Hypoxia, Brain / pathology
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Hypoxia, Brain / physiopathology
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Infant
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Infant, Newborn
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Seizures / complications*
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Seizures / etiology*
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Seizures / pathology
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Seizures / physiopathology
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Seizures, Febrile / complications
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Seizures, Febrile / etiology
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Seizures, Febrile / pathology
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Seizures, Febrile / physiopathology