Developmental seizures induced by common early-life insults: short- and long-term effects on seizure susceptibility

Ment Retard Dev Disabil Res Rev. 2000;6(4):253-7. doi: 10.1002/1098-2779(2000)6:4<253::AID-MRDD4>3.0.CO;2-P.

Abstract

The immature brain is highly susceptible to seizures induced by a variety of insults, including hypoxia, fever, and trauma. Unlike early life epilepsy associated with congenital dysplasias or genetic abnormalities, insults induce a hyperexcitable state in a previously normal brain. Here we evaluate the epileptogenic effects of seizure-inducing stimuli on the developing brain, and the age and regional specificity of these effects.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Age Factors
  • Brain / growth & development*
  • Brain / pathology
  • Brain / physiopathology
  • Brain Injuries / complications*
  • Brain Injuries / pathology
  • Brain Injuries / physiopathology
  • Causality
  • Child
  • Child, Preschool
  • Disease Models, Animal
  • Epilepsy / etiology*
  • Epilepsy / pathology
  • Epilepsy / physiopathology
  • Epilepsy, Temporal Lobe / etiology
  • Epilepsy, Temporal Lobe / pathology
  • Epilepsy, Temporal Lobe / physiopathology
  • Humans
  • Hypoxia, Brain / complications
  • Hypoxia, Brain / pathology
  • Hypoxia, Brain / physiopathology
  • Infant
  • Infant, Newborn
  • Seizures / complications*
  • Seizures / etiology*
  • Seizures / pathology
  • Seizures / physiopathology
  • Seizures, Febrile / complications
  • Seizures, Febrile / etiology
  • Seizures, Febrile / pathology
  • Seizures, Febrile / physiopathology