Myelodysplastic syndrome and a nonrandom chromosomal abnormality t(1;19): an indolent pathologic entity

D L Forrest; S Couban; T J Nevill; C Y Lee; P J Welch

doi:10.1016/s0165-4608(00)00294-6

Myelodysplastic syndrome and a nonrandom chromosomal abnormality t(1;19): an indolent pathologic entity

Cancer Genet Cytogenet. 2000 Oct 15;122(2):134-6. doi: 10.1016/s0165-4608(00)00294-6.

Authors

D L Forrest¹, S Couban, T J Nevill, C Y Lee, P J Welch

Affiliation

¹ Division of Hematology and Department of Pathology, Queen Elizabeth II Health Sciences Centre, Izaak Walton Grace Health Science Centre, Dalhousie University, Halifax, Nova Scotia, Canada. dforrest@is.dal.ca

PMID: 11106825
DOI: 10.1016/s0165-4608(00)00294-6

Abstract

The chromosomal abnormality t(1;19) is an infrequent finding in adult hematopoietic malignancies. This is only the second report of t(1;19) in association with myelodysplastic syndrome in which there was an apparent excellent response to oral cyclosporin A and a very indolent clinical course.

Publication types

Case Reports

MeSH terms

Adolescent
Chromosomes, Human, Pair 1 / genetics*
Chromosomes, Human, Pair 19 / genetics*
Female
Humans
Karyotyping
Myelodysplastic Syndromes / genetics*
Myelodysplastic Syndromes / pathology
Translocation, Genetic*