Pranlukast protects leukotriene C4- and D4-induced epithelial cell impairment of the nasal mucosa in vitro

K Hisamatsu; M Nakajima

doi:10.1016/s0024-3205(00)00856-0

Pranlukast protects leukotriene C4- and D4-induced epithelial cell impairment of the nasal mucosa in vitro

Life Sci. 2000 Oct 20;67(22):2767-73. doi: 10.1016/s0024-3205(00)00856-0.

Authors

K Hisamatsu¹, M Nakajima

Affiliation

¹ Department of Otorhinolaryngology, Surugadai Nihon University Hospital School of Medicine, Tokyo, Japan. kenhisa@med.nihon-u.ac.jp

PMID: 11105993
DOI: 10.1016/s0024-3205(00)00856-0

Abstract

To investigate the effect of pranlukast on leukotriene- induced airway mucosal epithelial dysfunction, samples of human nasal mucosa obtained during surgery for facial trauma were exposed to leukotriene C4 and/or D4 and observed on a TV screen magnified x 2,500. Leukotriene C4- and D4-induced ciliary inhibition and delayed mucosal surface alterations appeared several hours later. Pranlukast prevented both the mucosal epithelial cell dysfunction and the delayed epithelial cell alteration.

MeSH terms

Adult
Cells, Cultured
Chromones / pharmacology*
Cilia / drug effects
Cilia / physiology*
Humans
Kinetics
Leukotriene Antagonists / pharmacology*
Leukotriene C4 / antagonists & inhibitors
Leukotriene C4 / pharmacology*
Leukotriene D4 / antagonists & inhibitors
Leukotriene D4 / pharmacology*
Male
Nasal Mucosa / cytology*
Nasal Mucosa / drug effects
Nasal Mucosa / physiology*
Time Factors

Substances

Chromones
Leukotriene Antagonists
Leukotriene C4
Leukotriene D4
pranlukast