An overview of the structures of protein-DNA compl...[Genome Biol. 2000]

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1: Genome Biol. 2000;1(1):REVIEWS001. Epub 2000 Jun 9. Links

An overview of the structures of protein-DNA complexes.

Luscombe NM, Austin SE, Berman HM, Thornton JM.

Biomolecular Structure and Modelling Unit, Department of Biochemistry and Molecular Biology, University College, Gower Street, London WC1E 6BT, UK. nick@biochem.ucl.ac.uk

On the basis of a structural analysis of 240 protein-DNA complexes contained in the Protein Data Bank (PDB), we have classified the DNA-binding proteins involved into eight different structural/functional groups, which are further classified into 54 structural families. Here we present this classification and review the functions, structures and binding interactions of these protein-DNA complexes.

PMID: 11104519 [PubMed - indexed for MEDLINE]

PMCID: PMC138832

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