Abstract
On the basis of a structural analysis of 240 protein-DNA complexes contained in the Protein Data Bank (PDB), we have classified the DNA-binding proteins involved into eight different structural/functional groups, which are further classified into 54 structural families. Here we present this classification and review the functions, structures and binding interactions of these protein-DNA complexes.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Crystallography, X-Ray
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DNA / chemistry*
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DNA / metabolism
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DNA-Binding Proteins / chemistry*
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DNA-Binding Proteins / classification
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DNA-Binding Proteins / physiology
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Humans
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Macromolecular Substances
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Structure-Activity Relationship
Substances
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DNA-Binding Proteins
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Macromolecular Substances
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DNA