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Nat Genet. 2000 Dec;26(4):455-9.

Fgf8 is required for outgrowth and patterning of the limbs.

Author information

  • 1Department of Pediatrics and Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA.

Abstract

The expression pattern and activity of fibroblast growth factor-8 (FGF8) in experimental assays indicate that it has important roles in limb development, but early embryonic lethality resulting from mutation of Fgf8 in the germ line of mice has prevented direct assessment of these roles. Here we report that conditional disruption of Fgf8 in the forelimb of developing mice bypasses embryonic lethality and reveals a requirement for Fgf8 in the formation of the stylopod, anterior zeugopod and autopod. Lack of Fgf8 in the apical ectodermal ridge (AER) alters expression of other Fgf genes, Shh and Bmp2.

PMID:
11101845
[PubMed - indexed for MEDLINE]
PMCID:
PMC2001274
Free PMC Article

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