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Nature. 2000 Nov 23;408(6811):433-9.

The DNA damage response: putting checkpoints in perspective.

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  • 1Department of Oncology Research, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA.

Abstract

The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development. Organisms respond to chromosomal insults by activating a complex damage response pathway. This pathway regulates known responses such as cell-cycle arrest and apoptosis (programmed cell death), and has recently been shown to control additional processes including direct activation of DNA repair networks.

PMID:
11100718
[PubMed - indexed for MEDLINE]
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