Nature. 2000 Nov 23;408(6811):433-9.

The DNA damage response: putting checkpoints in perspective.

Source

Department of Oncology Research, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA.

Abstract

The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development. Organisms respond to chromosomal insults by activating a complex damage response pathway. This pathway regulates known responses such as cell-cycle arrest and apoptosis (programmed cell death), and has recently been shown to control additional processes including direct activation of DNA repair networks.

PMID:: 11100718; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Related citations

Review [Cell cycle, mitosis and therapeutic applications]. [Bull Cancer. 2011]
Review [Cell cycle, mitosis and therapeutic applications].
Levy A, Albiges-Sauvin L, Massard C, Soria JC, Deutsch E. Bull Cancer. 2011 Oct; 98(9):1037-45.
Review The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. [Adv Cancer Res. 2010]
Review The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer.
Smith J, Tho LM, Xu N, Gillespie DA. Adv Cancer Res. 2010; 108:73-112.
Review DNA double-strand breaks: signaling, repair and the cancer connection. [Nat Genet. 2001]
Review DNA double-strand breaks: signaling, repair and the cancer connection.
Khanna KK, Jackson SP. Nat Genet. 2001 Mar; 27(3):247-54.
Review DNA damage checkpoint, damage repair, and genome stability. [Yi Chuan Xue Bao. 2006]
Review DNA damage checkpoint, damage repair, and genome stability.
Liu WF, Yu SS, Chen GJ, Li YZ. Yi Chuan Xue Bao. 2006 May; 33(5):381-90.
G2 damage checkpoints: what is the turn-on? [J Cell Sci. 2005]
G2 damage checkpoints: what is the turn-on?
O'Connell MJ, Cimprich KA. J Cell Sci. 2005 Jan 1; 118(Pt 1):1-6.

See reviews... See all...

Cited by over 100 PubMed Central articles

Administration of ON 01210.Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response. [Radiat Oncol. 2012]
Administration of ON 01210.Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response.
Suman S, Maniar M, Fornace AJ Jr, Datta K. Radiat Oncol. 2012 Jan 20; 7:6. Epub 2012 Jan 20.
DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway. [Cell Death Dis. 2012]
DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway.
Kang MA, So EY, Simons AL, Spitz DR, Ouchi T. Cell Death Dis. 2012 Jan 12; 3:e249. Epub 2012 Jan 12.
The putative metal coordination motif in the endonuclease domain of human Parvovirus B19 NS1 is critical for NS1 induced S phase arrest and DNA damage. [Int J Biol Sci. 2012]
The putative metal coordination motif in the endonuclease domain of human Parvovirus B19 NS1 is critical for NS1 induced S phase arrest and DNA damage.
Kivovich V, Gilbert L, Vuento M, Naides SJ. Int J Biol Sci. 2012; 8(1):79-92. Epub 2011 Nov 24.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

The DNA damage response: putting checkpoints in perspective.
The DNA damage response: putting checkpoints in perspective.
Nature. 2000 Nov 23 ;408(6811):433-9.

PubMed
The association of stigma with self-reported access to medical care and antiretr...
The association of stigma with self-reported access to medical care and antiretroviral therapy adherence in persons living with HIV/AIDS.
J Gen Intern Med. 2009 Oct ;24(10):1101-8. Epub 2009 Aug 4 .

PubMed
Gastric asthma: an unrecognized disease with an unsuspected frequency.
Gastric asthma: an unrecognized disease with an unsuspected frequency.
J Asthma. 1999 Jun ;36(4):315-25.

PubMed
Management of gastro-oesophageal reflux disease in general practice.
Management of gastro-oesophageal reflux disease in general practice.
BMJ. 2001 Feb 10 ;322(7282):344-7.

PubMed
Gastroesophageal reflux disease and asthma: the two are directly related.
Gastroesophageal reflux disease and asthma: the two are directly related.
Am J Med. 2000 Mar 6 ;108 Suppl 4a:153S-158S.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

The DNA damage response: putting checkpoints in perspective.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Related citations

Cited by over 100 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information