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Maturitas. 2000 Nov 30;37(1):15-26.

Heritability and risk factors of uterine fibroids--the Finnish Twin Cohort study.

Author information

  • 1Tampere School of Public Health, University of Tampere, Tampere, FIN-33014, Finland. Riitta.Luoto@uta.fi

Abstract

OBJECTIVES:

Our aim was to study heritability, risk factors and hospitalization for uterine fibroids.

METHODS:

A random sample of 80 MZ and 80 DZ twins from the Finnish Twin Cohort were invited and 51% of the eligible women (n=82, 17 MZ and 16 DZ pairs, 40-47 years, mean age 43.0), underwent a transvaginal ultrasound. The entire cohort of 13872 women was linked to the national hospital discharge registry 1972-1990.

RESULTS:

Prevalence of fibroids was 66% and the average number of fibroids 1.7. The casewise concordance for being hospitalized for uterine fibroids was higher in MZ (0.31, 95% CI 0.24-0.37) than in DZ pairs (0.18, 95% CI 0.14-0.22). The proportion of variance in liability to fibroid hospitalization accounted for by genetic factors was 54.8% (95% CI 46.2-62.7%). Women with fibroids had higher body mass index (23.7 vs 21.7, P=0.0086), lower age at first birth (25.7 vs 29.3, P=0.012) and higher parity (3+ children 48.2 vs 29.6%, P=0.009) than women without fibroids. Risk ratio (RR) for fibroids in a MZ twin whose sister had been diagnosed with fibroids was 1.1 (95% CI 0.08;15), for a DZ twin 1.1 (95% CI 0.16;8.8) and for all twins 1.3 (95% CI 0.3; 6.1). Intraclass correlation for the number of fibroids was 0.24 for MZ and 0.11 for DZ twins, yielding an heritability estimate of 0.26.

CONCLUSION:

Reproductive and anthropometric factors may have at least as large role in pathogenesis of fibroids than genetic factors.

PMID:
11099869
[PubMed - indexed for MEDLINE]
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