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Science. 2000 Dec 1;290(5497):1717-21.

Autophagy as a regulated pathway of cellular degradation.

Author information

  • 1Department of Biology, University of Michigan, 830 North University, Ann Arbor, MI 48109-1048, USA. klionsky@umich.edu

Abstract

Macroautophagy is a dynamic process involving the rearrangement of subcellular membranes to sequester cytoplasm and organelles for delivery to the lysosome or vacuole where the sequestered cargo is degraded and recycled. This process takes place in all eukaryotic cells. It is highly regulated through the action of various kinases, phosphatases, and guanosine triphosphatases (GTPases). The core protein machinery that is necessary to drive formation and consumption of intermediates in the macroautophagy pathway includes a ubiquitin-like protein conjugation system and a protein complex that directs membrane docking and fusion at the lysosome or vacuole. Macroautophagy plays an important role in developmental processes, human disease, and cellular response to nutrient deprivation.

PMID:
11099404
[PubMed - indexed for MEDLINE]
PMCID:
PMC2732363
Free PMC Article
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