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Bioinformatics. 2000 Aug;16(8):741-2.

A comparison of signal sequence prediction methods using a test set of signal peptides.

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  • 1EMBL Outstation Hinxton - The European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.


We describe the creation of a test set containing secretory and non-secretory proteins. Five existing prediction programs for signal sequences and their cleavage sites are compared on the basis of this test set: SPScan, SigCleave, SignalP V1.1, SignalP V2.0. b2-HMM and SignalP V2.0.b2-NN.

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