J Autism Dev Disord. 2000 Oct;30(5):427-35.

Repetitive thoughts and behavior in pervasive developmental disorders: treatment with serotonin reuptake inhibitors.

Source

Department of Psychiatry, Indiana University School of Medicine, Indianapolis, USA. cmcdougl@iupui.edu

Abstract

Repetitive thoughts and behavior are considered integral and core components of autistic disorder. Results from recent studies suggest that the types of repetitive thoughts and behavior of adults with autism and those with obsessive-compulsive disorder (OCD) may be different. Serotonin reuptake inhibitors (SRIs), the primary drug treatment for patients with OCD, may reduce the repetitive phenomena of some autistic patients. Two controlled studies of the nonselective SRI clomipramine have shown the drug to be more efficacious than the relatively selective norepinephrine reuptake inhibitor desipramine and placebo in children with autism. One controlled study of the selective SRI fluvoxamine found it to be significantly better than placebo for reducing repetitive phenomena and aggression in adults with autistic disorder. Additional research is needed.

PMID:: 11098879; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

DESIPRAMINE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Lack of efficacy of citalopram in children with autism spectrum disorders and high levels of repetitive behavior: citalopram ineffective in children with autism. [Arch Gen Psychiatry. 2009]
Lack of efficacy of citalopram in children with autism spectrum disorders and high levels of repetitive behavior: citalopram ineffective in children with autism.
King BH, Hollander E, Sikich L, McCracken JT, Scahill L, Bregman JD, Donnelly CL, Anagnostou E, Dukes K, Sullivan L, et al. Arch Gen Psychiatry. 2009 Jun; 66(6):583-90.
Clomipramine in adults with pervasive developmental disorders: a prospective open-label investigation. [J Child Adolesc Psychopharmaco...]
Clomipramine in adults with pervasive developmental disorders: a prospective open-label investigation.
Brodkin ES, McDougle CJ, Naylor ST, Cohen DJ, Price LH. J Child Adolesc Psychopharmacol. 1997 Summer; 7(2):109-21.
Multicenter double-blind comparison of sertraline and desipramine for concurrent obsessive-compulsive and major depressive disorders. [Arch Gen Psychiatry. 2000]
Multicenter double-blind comparison of sertraline and desipramine for concurrent obsessive-compulsive and major depressive disorders.
Hoehn-Saric R, Ninan P, Black DW, Stahl S, Greist JH, Lydiard B, McElroy S, Zajecka J, Chapman D, Clary C, et al. Arch Gen Psychiatry. 2000 Jan; 57(1):76-82.
Review The use of selective serotonin reuptake inhibitors in autism and related disorders. [J Child Adolesc Psychopharmaco...]
Review The use of selective serotonin reuptake inhibitors in autism and related disorders.
Posey DJ, Erickson CA, Stigler KA, McDougle CJ. J Child Adolesc Psychopharmacol. 2006 Feb-Apr; 16(1-2):181-6.
Review A review of pharmacologic treatments for obsessive-compulsive disorder. [Psychiatr Serv. 2003]
Review A review of pharmacologic treatments for obsessive-compulsive disorder.
Kaplan A, Hollander E. Psychiatr Serv. 2003 Aug; 54(8):1111-8.

See reviews... See all...

Cited by 3 PubMed Central articles

Obsessive-compulsive spectrum disorders. [Dialogues Clin Neurosci. 2003]
Obsessive-compulsive spectrum disorders.
Allen A, King A, Hollander E. Dialogues Clin Neurosci. 2003 Sep; 5(3):259-71.
Review Advances in the treatment of fragile X syndrome. [Pediatrics. 2009]
Review Advances in the treatment of fragile X syndrome.
Hagerman RJ, Berry-Kravis E, Kaufmann WE, Ono MY, Tartaglia N, Lachiewicz A, Kronk R, Delahunty C, Hessl D, Visootsak J, et al. Pediatrics. 2009 Jan; 123(1):378-90.
Review Developing drugs for core social and communication impairment in autism. [Child Adolesc Psychiatr Clin N...]
Review Developing drugs for core social and communication impairment in autism.
Posey DJ, Erickson CA, McDougle CJ. Child Adolesc Psychiatr Clin N Am. 2008 Oct; 17(4):787-801, viii-ix.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Repetitive thoughts and behavior in pervasive developmental disorders: treatment...
Repetitive thoughts and behavior in pervasive developmental disorders: treatment with serotonin reuptake inhibitors.
J Autism Dev Disord. 2000 Oct ;30(5):427-35.

PubMed
Depression in the internship.
Depression in the internship.
Dis Nerv Syst. 1975 Jan ;36(1):26-9.

PubMed
The relationship between depressive and vital exhaustion symptomatology post-myo...
The relationship between depressive and vital exhaustion symptomatology post-myocardial infarction.
Acta Psychiatr Scand. 2000 Nov ;102(5):359-65.

PubMed
Brain processing of visual sexual stimuli in human males.
Brain processing of visual sexual stimuli in human males.
Hum Brain Mapp. 2000 Nov ;11(3):162-77.

PubMed
Cellular and neurochemical remodeling of the spinal cord in bone cancer pain.
Cellular and neurochemical remodeling of the spinal cord in bone cancer pain.
Prog Brain Res. 2000 ;129:389-97.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Repetitive thoughts and behavior in pervasive developmental disorders: treatment with serotonin reuptake inhibitors.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information