Arthritis Res. 1999;1(1):21-4. Epub 1999 Jul 8.

Lessons learned from gene transfer approaches.

Evans CH, Ghivizzani SC, Lechman ER, Mi Z, Jaffurs D, Robbins PD.

Source

Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA. cevans@vms.cis.pitt.edu

Abstract

Recent technological advances allow the transfer of genes to the synovial lining of joints. As well as opening novel opportunities for therapy, these techniques provide valuable new tools for the study of synovitis and other aspects of the biology of joints in health and disease. This article reviews briefly the results of experiments in which selected genes have been transferred to the knee joints of healthy rabbits and rabbits with antigen-induced arthritis.

Comment in

Arthritis Res. 1999;1(1):5-9.

PMID:: 11094409; [PubMed - indexed for MEDLINE]
PMCID:: PMC128865

Free PMC Article

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Supplemental Content

Save items

Related citations in PubMed

The contralateral effect conferred by intra-articular adenovirus-mediated gene transfer of viral IL-10 is specific to the immunizing antigen. [Gene Ther. 2003]
The contralateral effect conferred by intra-articular adenovirus-mediated gene transfer of viral IL-10 is specific to the immunizing antigen.
Lechman ER, Keravala A, Nash J, Kim SH, Mi Z, Robbins PD. Gene Ther. 2003 Nov; 10(24):2029-35.
Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees. [Arthritis Res Ther. 2003]
Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees.
Mi Z, Ghivizzani SC, Lechman E, Glorioso JC, Evans CH, Robbins PD. Arthritis Res Ther. 2003; 5(3):R132-9. Epub 2003 Mar 12.
Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium. [Gene Ther. 2003]
Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium.
Yao Q, Wang S, Gambotto A, Glorioso JC, Evans CH, Robbins PD, Ghivizzani SC, Oligino TJ. Gene Ther. 2003 Jun; 10(12):1055-60.
Review The SCID mouse model: novel therapeutic targets - lessons from gene transfer. [Springer Semin Immunopathol. 2...]
Review The SCID mouse model: novel therapeutic targets - lessons from gene transfer.
Pierer M, Müller-Ladner U, Pap T, Neidhart M, Gay RE, Gay S. Springer Semin Immunopathol. 2003 Aug; 25(1):65-78.
Review Recent developments in molecular therapeutic approaches for rheumatoid arthritis. [Curr Opin Mol Ther. 2004]
Review Recent developments in molecular therapeutic approaches for rheumatoid arthritis.
Woods A, Hobson P, Klavinskis LS. Curr Opin Mol Ther. 2004 Aug; 6(4):395-402.

See reviews... See all...

Cited by 2 PubMed Central articles

Cells of the synovium in rheumatoid arthritis. Macrophages. [Arthritis Res Ther. 2007]
Cells of the synovium in rheumatoid arthritis. Macrophages.
Kinne RW, Stuhlmüller B, Burmester GR. Arthritis Res Ther. 2007; 9(6):224.
Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees. [Arthritis Res Ther. 2003]
Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees.
Mi Z, Ghivizzani SC, Lechman E, Glorioso JC, Evans CH, Robbins PD. Arthritis Res Ther. 2003; 5(3):R132-9. Epub 2003 Mar 12.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Lessons learned from gene transfer approaches.
Lessons learned from gene transfer approaches.
Arthritis Res. 1999 ;1(1):21-4. Epub 1999 Jul 8 .

PubMed
Laboratory sleep correlates of nightmare complaint in PTSD inpatients.
Laboratory sleep correlates of nightmare complaint in PTSD inpatients.
Biol Psychiatry. 2000 Dec 1 ;48(11):1081-7.

PubMed
Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antig...
Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line.
Mol Cell Biol. 2000 Dec ;20(24):9149-61.

PubMed
A multicentre, randomized, double-blind, placebo-controlled trial of naltrexone ...
A multicentre, randomized, double-blind, placebo-controlled trial of naltrexone in the treatment of alcohol dependence or abuse.
Alcohol Alcohol. 2000 Nov-Dec ;35(6):587-93.

PubMed
Identification of human cytochrome P450s involved in the formation of all-trans-...
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
Mol Pharmacol. 2000 Dec ;58(6):1341-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Lessons learned from gene transfer approaches.

Source

Abstract

Comment in

MeSH Terms

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information