FEBS Lett. 2000 Nov 24;485(2-3):135-41.

Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3).

Kaptein A, Jansen M, Dilaver G, Kitson J, Dash L, Wang E, Owen MJ, Bodmer JL, Tschopp J, Farrow SN.

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Cell Biology Department, GlaxoWellcome Medicines Research Centre, Stevenage, UK.

Abstract

WSL-1/TRAMP (DR3) is a member of the tumour necrosis factor (TNF) receptor superfamily which exhibits effects on NF-kappaB activation and apoptosis. TWEAK, a novel TNF-related molecule, has been proposed as the ligand for this receptor. Utilising both human and murine TWEAK ligand, it is shown that TWEAK and WSL-1/TRAMP do not interact in an in vitro binding assay and that TWEAK binds strongly to cells that do not express WSL-1/TRAMP on the cell surface. Biological activity of TWEAK is also observed in these cells. Finally, cells isolated from WSL-1/TRAMP knockout mice are shown to retain their ability to interact with TWEAK. These results suggest that WSL-1/TRAMP is not the major receptor for TWEAK

PMID:: 11094155; [PubMed - indexed for MEDLINE]

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TWEAK can induce cell death via endogenous TNF and TNF receptor 1. [Eur J Immunol. 1999]
TWEAK can induce cell death via endogenous TNF and TNF receptor 1.
Schneider P, Schwenzer R, Haas E, Mühlenbeck F, Schubert G, Scheurich P, Tschopp J, Wajant H. Eur J Immunol. 1999 Jun; 29(6):1785-92.
Multiple pathways of TWEAK-induced cell death. [J Immunol. 2002]
Multiple pathways of TWEAK-induced cell death.
Nakayama M, Ishidoh K, Kayagaki N, Kojima Y, Yamaguchi N, Nakano H, Kominami E, Okumura K, Yagita H. J Immunol. 2002 Jan 15; 168(2):734-43.
TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). [Immunity. 1997]
TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95).
Bodmer JL, Burns K, Schneider P, Hofmann K, Steiner V, Thome M, Bornand T, Hahne M, Schröter M, Becker K, et al. Immunity. 1997 Jan; 6(1):79-88.
Review TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor. [Cytokine Growth Factor Rev. 2003]
Review TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor.
Wiley SR, Winkles JA. Cytokine Growth Factor Rev. 2003 Jun-Aug; 14(3-4):241-9.
Review TRAIL-induced signalling and apoptosis. [Toxicol Lett. 2003]
Review TRAIL-induced signalling and apoptosis.
MacFarlane M. Toxicol Lett. 2003 Apr 4; 139(2-3):89-97.

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Cited by 11 PubMed Central articles

Functional expression of TWEAK and the receptor Fn14 in human malignant ovarian tumors: possible implication for ovarian tumor intervention. [PLoS One. 2013]
Functional expression of TWEAK and the receptor Fn14 in human malignant ovarian tumors: possible implication for ovarian tumor intervention.
Gu L, Dai L, Cao C, Zhu J, Ding C, Xu HB, Qiu L, Di W. PLoS One. 2013; 8(3):e57436. Epub 2013 Mar 4.
Aberrant expression and function of death receptor-3 and death decoy receptor-3 in human cancer. [Exp Ther Med. 2011]
Aberrant expression and function of death receptor-3 and death decoy receptor-3 in human cancer.
Ge Z, Sanders AJ, Ye L, Jiang WG. Exp Ther Med. 2011 Mar; 2(2):167-172. Epub 2011 Jan 20.
A Bioinformatics Resource for TWEAK-Fn14 Signaling Pathway. [J Signal Transduct. 2012]
A Bioinformatics Resource for TWEAK-Fn14 Signaling Pathway.
Bhattacharjee M, Raju R, Radhakrishnan A, Nanjappa V, Muthusamy B, Singh K, Kuppusamy D, Lingala BT, Pan A, Mathur PP, et al. J Signal Transduct. 2012; 2012:376470. Epub 2012 May 9.

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