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Neurology. 2000 Nov 28;55(10):1575-7.

18F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies.

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  • 1Department of Geriatric Medicine, Tohoku University School of Medicine, and the Cyclotron and Radioisotope Center , Tohoku University, Sendai, Miyagi, Japan.


Using (18)F-fluorodopa PET and a constant 0.0062 influx rate in the putamen, dementia with Lewy bodies (n = 7) was distinguished from AD (n = 10) with a sensitivity of 86% and a specificity of 100%. A constant 0.0071 influx rate in the caudate yielded a sensitivity of 71% and a specificity of 100% for distinction of the two disorders. Despite a limited sample size, these findings suggest that assessing nigrostriatal dopaminergic function with (18)F-fluorodopa PET may be a useful diagnostic aid in cases of dementia with Lewy bodies while patients are alive.

[PubMed - indexed for MEDLINE]
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