Trends Endocrinol Metab. 2000 Dec;11(10):410-6.

Lipoatrophy revisited.

Reitman ML, Arioglu E, Gavrilova O, Taylor SI.

Source

Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Room 8N-250, 10 Center Drive, Bethesda, MD 20892-1770, USA. mlr@helix.nih.gov

Abstract

The lipoatrophy syndromes are a heterogeneous group of syndromes characterized by a paucity of adipose tissue. Severe lipoatrophy is associated with insulin-resistant diabetes mellitus (DM). The loss of adipose tissue can have a genetic, immune, or infectious/drug-associated etiology. Causative mutations have been identified in patients for one form of partial lipoatrophy--Dunnigan-type familial partial lipodystrophy. Experiments using lipoatrophic mice demonstrate that the diabetes results from the lack of fat and that leptin deficiency is a contributing factor. Thiazolidinedione therapy improves metabolic control in lipoatrophic patients; the efficacy of leptin treatment is currently being investigated.

PMID:: 11091118; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

Review

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Diabetes Type 2 - MedlinePlus Health Information

Supplemental Content

Related citations

Review Diseases of adipose tissue: genetic and acquired lipodystrophies. [Biochem Soc Trans. 2005]
Review Diseases of adipose tissue: genetic and acquired lipodystrophies.
Capeau J, Magré J, Lascols O, Caron M, Béréziat V, Vigouroux C, Bastard JP. Biochem Soc Trans. 2005 Nov; 33(Pt 5):1073-7.
Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy. [Diabetes. 2002]
Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy.
Colombo C, Cutson JJ, Yamauchi T, Vinson C, Kadowaki T, Gavrilova O, Reitman ML. Diabetes. 2002 Sep; 51(9):2727-33.
Review Lipodystrophies. [Am J Med. 2000]
Review Lipodystrophies.
Garg A. Am J Med. 2000 Feb; 108(2):143-52.
Review Lipodystrophy syndromes. [Dermatol Clin. 2008]
Review Lipodystrophy syndromes.
Herranz P, de Lucas R, Pérez-España L, Mayor M. Dermatol Clin. 2008 Oct; 26(4):569-78, ix.
Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes. [Diabetes. 2001]
Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes.
Ebihara K, Ogawa Y, Masuzaki H, Shintani M, Miyanaga F, Aizawa-Abe M, Hayashi T, Hosoda K, Inoue G, Yoshimasa Y, et al. Diabetes. 2001 Jun; 50(6):1440-8.

See reviews... See all...

Cited by 18 PubMed Central articles

Disruption of hepatic leptin signaling protects mice from age- and diet-related glucose intolerance. [Diabetes. 2010]
Disruption of hepatic leptin signaling protects mice from age- and diet-related glucose intolerance.
Huynh FK, Levi J, Denroche HC, Gray SL, Voshol PJ, Neumann UH, Speck M, Chua SC, Covey SD, Kieffer TJ. Diabetes. 2010 Dec; 59(12):3032-40. Epub 2010 Sep 28.
The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia. [J Clin Endocrinol Metab. 2009]
The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia.
Mulligan K, Khatami H, Schwarz JM, Sakkas GK, DePaoli AM, Tai VW, Wen MJ, Lee GA, Grunfeld C, Schambelan M. J Clin Endocrinol Metab. 2009 Apr; 94(4):1137-44. Epub 2009 Jan 27.
Lipin1 is a key factor for the maturation and maintenance of adipocytes in the regulatory network with CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma 2. [J Biol Chem. 2008]
Lipin1 is a key factor for the maturation and maintenance of adipocytes in the regulatory network with CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma 2.
Koh YK, Lee MY, Kim JW, Kim M, Moon JS, Lee YJ, Ahn YH, Kim KS. J Biol Chem. 2008 Dec 12; 283(50):34896-906. Epub 2008 Oct 16.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Lipoatrophy revisited.
Lipoatrophy revisited.
Trends Endocrinol Metab. 2000 Dec ;11(10):410-6.

PubMed
Influence of tear film and contact lens osmolality on ocular comfort in contact ...
Influence of tear film and contact lens osmolality on ocular comfort in contact lens wear.
Optom Vis Sci. 2009 Jul ;86(7):857-67.

PubMed
Prevention of atrial fibrillation.
Prevention of atrial fibrillation.
Curr Opin Cardiol. 2005 Sep ;20(5):417-23.

PubMed
Minimally interrupted cardiac resuscitation by emergency medical services for ou...
Minimally interrupted cardiac resuscitation by emergency medical services for out-of-hospital cardiac arrest.
JAMA. 2008 Mar 12 ;299(10):1158-65.

PubMed
Infidelity, trust, and condom use among Latino youth in dating relationships.
Infidelity, trust, and condom use among Latino youth in dating relationships.
Sex Transm Dis. 2009 Apr ;36(4):227-31.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: