Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Nature. 2000 Nov 9;408(6809):239-47.

Oxidants, oxidative stress and the biology of ageing.

Author information

  • 1Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute/National Institutes of Health, Bethesda, Maryland 20892-1622, USA. finkelt@nih.gov

Abstract

Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span.

PMID:
11089981
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk