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Neurology. 2000 Nov 14;55(9):1388-90.

Novel mutations in spastin gene and absence of correlation with age at onset of symptoms.

Author information

  • 1Department of Neurology, Northwestern Institute of Neurosciences, Northwestern University Medical School, Chicago, IL 60611, USA.

Abstract

Autosomal dominant hereditary spastic paraplegia is genetically heterogeneous, with at least five loci identified by linkage analysis. Recently, mutations in spastin were identified in SPG4, the most common locus for dominant hereditary spastic paraplegia that was previously mapped to chromosome 2p22. We identified five novel mutations in the spastin gene in five families with SPG4 mutations from North America and Tunisia and showed the absence of correlation between the predicted mutant spastin protein and age at onset of symptoms.

PMID:
11087788
[PubMed - indexed for MEDLINE]
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