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Arch Dis Child. 2000 Dec;83(6):488-91.

Safety and immunogenicity of a paediatric presentation of an influenza vaccine.

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  • 1Centro Materno-Infantil Maciel, Montevideo, Uruguay.

Abstract

BACKGROUND:

Flu vaccination in otherwise healthy infants and young children is important to prevent severe disease, as well as to control epidemic spread of influenza infection.

AIMS:

To examine the safety and immunogenicity of a paediatric presentation of a purified, inactivated, triton split influenza vaccine.

METHODS:

Two doses of the vaccine, provided in prefilled syringes of 0.25 ml, were administered, one month apart, to 67 children under 3 years of age.

RESULTS:

Nine cases of immediate reaction to vaccination (macules/papules) were observed after the second injection only. During the study period, 9% of children experienced at least one delayed local reaction, and 28% of children presented at least one systemic reaction. Almost all reactions were mild and transient. Immunogenicity results surpassed the European Community recommendations for a 0.50 ml dose of vaccine in adults.

CONCLUSION:

This paediatric formulation of inactivated flu vaccine appears safe and immunogenic in children from 6 months to 3 years of age; the convenient presentation in a prefilled syringe of 0.25 ml volume will facilitate administration of the dose recommended for young children.

PMID:
11087282
[PubMed - indexed for MEDLINE]
PMCID:
PMC1718589
Free PMC Article
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