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J Infect Dis. 2001 Jan 1;183(1):97-104. Epub 2000 Nov 15.

Immunologic memory 5 years after meningococcal A/C conjugate vaccination in infancy.

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  • 1Oxford Vaccine Group, Dept. of Pediatrics, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom. jenny.maclennan@ceid.ox.ac.uk

Abstract

Infant vaccination with meningococcal conjugates may provide long-term protection against disease. Antibody levels and immunologic memory were assessed in 5-year-old Gambian children who received meningococcal A/C conjugate vaccination (MenA/C) in infancy. At 2 years, they were randomized to receive a booster of MenA/C (conjugate group), meningococcal A/C polysaccharide (MPS group), or inactivated polio vaccine (IPV group). All groups were revaccinated with 10 microg MPS at 5 years of age, as were 39 previously unvaccinated age-matched control subjects. Before revaccination, titers were higher in the conjugate and MPS groups than in control subjects (P<.001); titers for the IPV group were similar to those for control subjects. Ten days after revaccination, the conjugate and IPV groups had similar serogroup C serum bactericidal antibody titers (3421 vs. 2790, respectively). These levels were significantly higher than those in the MPS (426) and control (485) groups (P<.001). Thus, immunologic memory was sustained for > or =5 years; however, MPS challenge at 2 years interfered with a subsequent memory response.

PMID:
11087205
[PubMed - indexed for MEDLINE]
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