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Am J Obstet Gynecol. 2000 Nov;183(5):1119-23.

Hindbrain herniation develops in surgically created myelomeningocele but is absent after repair in fetal lambs.

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  • 1Division of Pediatric Surgery, Department of Surgery, and The Fetal Treatment Center, University of California at San Francisco, 94143-0570, USA.

Abstract

OBJECTIVE:

The purpose of our study was to determine whether prenatal repair of myelomeningocele prevents or reverses hindbrain herniation in the sheep model.

STUDY DESIGN:

A myelomeningocele was surgically created in fetal sheep. One group was repaired later in utero; the others were delivered without repair. After delivery, lambs were assessed for the presence of hindbrain herniation.

RESULTS:

In all lambs that had not undergone repair of the myelomeningocele, severe hindbrain herniation developed, whereas the brains of all lambs that had undergone fetal repair were normal.

CONCLUSION:

Prenatal repair of myelomeningocele prevents or reverses development of hindbrain herniation in the fetal lamb model.

PMID:
11084552
[PubMed - indexed for MEDLINE]
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