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Trends Biochem Sci. 2000 Nov;25(11):555-60.

Mitochondrial genetics and disease.

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  • 1Depts of Neurology and of Genetics and Development, Columbia University, New York, NY 10032, USA. eas3@columbia.edu

Abstract

Mitochondrial respiratory chain diseases are a highly diverse group of disorders whose main unifying characteristic is the impairment of mitochondrial function. As befits an organelle containing gene products encoded by both mitochondrial DNA (mtDNA) and nuclear DNA (nDNA), these diseases can be caused by inherited errors in either genome, but a surprising number are sporadic, and a few are even caused by environmental factors.

PMID:
11084368
[PubMed - indexed for MEDLINE]
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