Send to

Choose Destination
See comment in PubMed Commons below
Trends Biochem Sci. 2000 Nov;25(11):555-60.

Mitochondrial genetics and disease.

Author information

  • 1Depts of Neurology and of Genetics and Development, Columbia University, New York, NY 10032, USA.


Mitochondrial respiratory chain diseases are a highly diverse group of disorders whose main unifying characteristic is the impairment of mitochondrial function. As befits an organelle containing gene products encoded by both mitochondrial DNA (mtDNA) and nuclear DNA (nDNA), these diseases can be caused by inherited errors in either genome, but a surprising number are sporadic, and a few are even caused by environmental factors.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk