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Trends Biochem Sci. 2000 Nov;25(11):548-55.

What does 'chromatin remodeling' mean?

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  • 1Dept of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.


The regulated alteration of chromatin structure, termed 'chromatin remodeling', can be accomplished by covalent modification of histones or by the action of ATP-dependent remodeling complexes. A variety of mechanisms can be used to remodel chromatin; some act locally on a single nucleosome and others act more broadly. It is critical to establish a direct connection between the remodeling events observed in vivo and the mechanistic capabilities of remodeling complexes in vitro.

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